| 名稱 | EGFR V769_D770insSFL/BaF3 |
| 型號 | CBP73221 |
| 報價 |  |
| 特點 | EGFR V769_D770insSFL/BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO |
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藥靶細胞株 > kinase激酶細胞株 > CBP73221EGFR V769_D770insSFL/BaF3
- 詳細內容
| CBP73221 | |
| I. Introduction | |
Cell Line Name： | EGFR V769_D770insSFL/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
EGFR (HER1), epidermal growth factor receptor, is a tyrosine kinase receptor, which activates RAS/RAF/MEK and PI3K/AKT/mTOR pathways, leading to increased cell proliferation and growth (PMID: 24312144). EGFR activating mutations, amplification, and overexpression are found in a variety of tumors, including non-small cell lung cancer (PMID: 26609494, PMID: 30284706) and colorectal cancer (PMID: 30243897), and the EGFRvIII variant is commonly found in glioblastoma (PMID: 30201736). | |
| III. Representative Data | |
1. WB of EGFR V769_D770insSFL/BaF3
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2. Anti-proliferation assay | |
