hDLL3/4T1 hDLL3/4T1 hDLL3/4T1
I. Background |
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DLL3 基因別名 SCDO1,其編碼的蛋白 DLL3 是一種跨膜蛋白,是 Notch 受體配體 Delta/Serrate/lag2(DSL)組的成員,在胚層的分離中,影響著體細胞邊界的形成。 DLL3 基因突變會導致嚴重的體節(jié)發(fā)生異常和脊椎肋骨發(fā)育不全。DLL3 是一種高度腫瘤選 擇性的細胞表面靶點,在正常肺癌組織及癌旁組織中不表達。DLL3 在多種腫瘤中表達上 調,在小細胞肺癌、乳腺癌、垂體瘤、急性髓系白血病中有促癌作用,但在肝癌 、神經膠 質瘤和惡性膠質瘤中卻發(fā)揮了抑癌作用。 |
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II. Introduction |
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Host Cell: | 4T1 |
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Expressed gene: | hDLL3 |
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Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Freeze Medium: | 90% FBS+10% DMSO |
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Culture Medium: | RPMI-1640+10%FBS+2 μg/ml puromycin |
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Mycoplasma Testing: | Negative |
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Storage: | Liquid nitrogen |
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III. Description of Host Cell Line |
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Organism: | Mouse |
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Tissue: | Mammary gland |
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Morphology: | Epithelial |
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Growth Properties: | Adherent |
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IV. Representative Data

Figure 1. Recombinant hDLL3/4T1 stably expressing hDLL3. |
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