hROR1/4T1 hROR1/4T1 hROR1/4T1
I. Background | | |
受體激酶樣孤兒受體(Receptor Tyrosine Kinase-like orphan receptor,ROR)是 Ⅰ型受體激酶(receptor tyrosine kinase,RTK)家族中的成員,是一類膜受體,主要 包括 ROR1 和 ROR2。其中 ROR1 主要通過參與細胞內與細胞間信號傳導,實現調節細胞 代謝、增殖、凋亡、分化、遷移、轉移等功能。ROR1 在正常組織中(除了原腸胚時期) 表達量較低,但 ROR1 在多種腫瘤細胞高度表達,包括乳腺癌、卵巢癌、腎癌、肺腺細胞 癌、胃癌等實體瘤細胞以及某些血液腫瘤細胞。 | | |
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II. Introduction | | |
Host Cell: | 4T1 | | |
Expressed gene: | hROR1 | | |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | | |
Freeze Medium: | 90% FBS+10% DMSO | | |
Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin | | |
Mycoplasma Testing: | Negative | | |
Storage: | Liquid nitrogen | | |
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III. Description of Host Cell Line | | |
Organism: | Mouse | | |
Tissue: | Mammary gland | | |
Morphology: | Epithelial | | |
Growth Properties: | Adherent | | |
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IV. Representative Data | | |

Figure 1. Recombinant hROR1/4T1 stably expressing ROR1. | |
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