| 名稱 | CSF3R T615A/BaF3 |
| 型號(hào) | CBP73252 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | CSF3R T615A/BaF3,母細(xì)胞：BaF3，CSF3R T615A 位于 Csf3r 蛋白跨膜結(jié)構(gòu)域附近的胞外結(jié)構(gòu)域內(nèi)（PMID：23656643）。預(yù)計(jì) T615A 會(huì)增強(qiáng) Csf3r 蛋白的功能，如培養(yǎng)物中轉(zhuǎn)化細(xì)胞增殖增加所證明的 （PMID: 23656643）。 |
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藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73252CSF3R T615A/BaF3
- 詳細(xì)內(nèi)容
CBP73252 | |
| I. Introduction | |
Cell Line Name： | CSF3R T615A/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
CSF3R T615A lies within the extracellular domain proximal to the transmembrane domain of the Csf3r protein (PMID: 23656643). T615A is predicted to confer a gain of function to the Csf3r protein, as demonstrated by increased proliferation of transformed cells in culture (PMID: 23656643). | |
| III. Representative Data | |
1.WB of CSF3R T615A/BaF3
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2. Anti-proliferation assay | |
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Figure 2. Anti-proliferation assay of three reference compounds on the CSF3R T615A/BaF3. | |
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