| 名稱 | CSF3R T618I/BaF3 |
| 型號 | CBP73253 |
| 報價 |  |
| 特點 | CSF3R T618I/BaF3,母細胞：BaF3，CSF3R T618I 位于 Csf3r 蛋白跨膜結(jié)構(gòu)域附近的胞外結(jié)構(gòu)域內(nèi)（PMID：23656643）。 T618I 賦予 Csf3r 蛋白功能增益，如培養(yǎng)的轉(zhuǎn)化細胞中增殖增加和下游 Jak-Stat 信號傳導(dǎo)增加所證明的（PMID：23656643）。 |
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藥靶細胞株 > kinase激酶細胞株 > CBP73253CSF3R T618I/BaF3
- 詳細內(nèi)容
CBP73253 | |
| I. Introduction | |
Cell Line Name： | CSF3R T618I/BaF3 |
Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Application: | Anti-proliferation assay and PD assay |
Freeze Medium: | 90% FBS+10% DMSO |
Complete Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Status: | Negative |
| II.Background | |
CSF3R T618I lies within the extracellular domain proximal to the transmembrane domain of the Csf3r protein (PMID: 23656643). T618I confers a gain of function to the Csf3r protein as demonstrated by increased proliferation and increased downstream Jak-Stat signaling in transformed cells in culture (PMID: 23656643). | |
| III. Representative Data | |
1.WB of CSF3R T618I/BaF3
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2. Anti-proliferation assay | |
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Figure 2. Anti-proliferation assay of three reference compounds on the CSF3R T618I/BaF3. | |
